We present the case of a 68-year-old woman with asymptomatic hyperparathyroidism incidentally discovered through a health examination. A subsequent thyroid sonogram revealed a homogenous left parathyroid hypoechoic lesion measuring approximately 11.3 × 5.9 mm2. Suspected to have parathyroid adenoma, the patient underwent an ultrasound-guided percutaneous radiofrequency ablation (RFA) after declining parathyroidectomy. The size of the parathyroid gland, Doppler ultrasound images, and calcium and intact parathyroid hormone (iPTH) levels were used to evaluate the effec of the RFA. After the RFA, no complications were reported. The patient’s follow-up calcium and iPTH levels gradually decreased. This case demonstrates the feasibility and safety of RFA as an alternative approach for treating parathyroid adenoma for patients who decline surgery. (J Taiwan Otolaryngol Head Neck Surg 2022; 57:309-315)
