台耳醫誌

Hypopharyngeal liposarcoma is an extremely rare type of soft tissue sarcoma.We report a case of a 60-year-old man presenting with progressive dysphagia and a foreign body sensation in the throat,which were notably aggravated by changes in head position- a symptom not previously described in similar cases.Despite thorough diagnostic imaging and endoscopy prior to further treatment,a definitive diagnosis remained elusive,with only a tumor-like lesion observed in the right hypopharynx,highlighting the diagnostic challenges often associated with this condition.The patient subsequently underwent transoral laser microsurgery,and histopathological analysis confirmed a well- differentiated liposarcoma characterized by MDM2 and CDK4 oncogene amplification. However,tumor cells were found near the resection margins,necessitating a second surgery to ensure clear margins.This case emphasizes the importance of careful surgical planning and margin assessment,even when clinical findings initially suggest benignity. Long-term follow-up is essential due to the risk of local recurrence,despite the tumor's low metastatic potential.This case adds to the limited literature on hypopharyngeal liposarcomas and highlights the need for a multimodal approach in diagnosis and treatment.(J Taiwan Otolaryngol Head Neck Surg 2025;59:132-139)