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台耳醫誌

雜誌專區 -第57卷第3期

原著 
Willingness of Patients with Alzheimer’s Disease and High Risk of Obstructive Sleep Apnea to Undergo Sleep Apnea Evaluation and Treatment: A Preliminary Study  僅供有效會員 登入會員查看全文
167~174 
英文 
Alzheimer’s disease、dementia、snoring、sleep apnea、willingness 
Yun-Ting Wang1,2,3 、Chin-Kuo Lin9 、Rou-Chen Shen1 、Yi-Chan Lee10 、Ming-Shao Tsai1,2,3,5* 、Sin-Yu Hsu2,4 、Hsueh-Yu Li2,5 、Li-Ang Lee2,5 、Yen-Chu Huang6 、Ying-Chih Huang7 、Jian-An Su8  
Department of Otolaryngology – Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi1 、Department of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi2 、Department of Otolaryngology – Head and Neck Surgery, Keelung Chang Gung Memorial Hospital, Keelung, TAIWAN3 、College of Medicine, Chang Gung University, Taoyuan4 、Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi5 、Department of Medical Education, Chiayi Chang Gung Memorial Hospital, Chiayi6 、Department of Otolaryngology – Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan7 、Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan8 、Department of Neurology, Chiayi Chang Gung Memorial Hospital, Chiayi, and9 、Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi10  
BACKGROUND: Obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) areassociated. OSA doubles the risk of AD. Patients with AD and OSA who receive continuous positive airway pressure (CPAP) therapy experience slower dementia progression. However, patients with AD might be unwilling to undergo OSA assessment and treatment because of their dementia symptoms, poor personal motivation, or insufficient family support. Therefore, we investigated the willingness of patients with AD to undergo OSA examination and treatment.
METHODS: This prospective study collected data from consecutive patients with new diagnoses of AD at Chiayi Chang Gung Hospital from January to March 2021. Sex, age, Mini–Mental State Examination (MMSE) score, STOP-Bang questionnaire score, and willingness to undergo OSA evaluation and treatment were analyzed.
RESULTS: In total, 68 patients (27 male, 41 female) with AD were included. Their mean age was 78.9 (56–93) years, and their mean MMSE score was 17.9 (3–23) points. Their mean STOP-Bang score was 3.49 (range, 1–7), and 75% of the patients scored .3 (representing a high risk of OSA). Among the 51 patients who scored .3 on the STOP Bang questionnaire, only 16 (31.4%) were willing to visit the otolaryngology clinic, and only 3 (5.88%) of them were willing to undergo polysomnography. These three patients had moderate or severe OSA; they were all treated with CPAP for more than 1 month, but only one continued CPAP through 6 months of follow-up.
CONCLUSIONS: Patients with AD dementia exhibit low willingness to undergo OSA evaluation and treatment. Therefore, early detection and treatment of OSA before dementia develops may be a better strategy. Further in-depth research remains to be done. (J Taiwan Otolaryngol Head Neck Surg 2022; 57:167-174)
 
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